Certificate error from web portal after application server certificate change


We are getting certification validation error on web portal searches after renewing the application server certificate. Below is the error on web server logs:

At the time of the exception, the container was:
  Resolving VI.WebRuntime.Data.SearchHelper,(none) (mapped from QBM.CompositionApi.Data.ISearchHelper, (none))
  Calling constructor VI.WebRuntime.Data.SearchHelper()
 ---> System.AggregateException: One or more errors occurred. ---> System.Reflection.TargetInvocationException: Exception has been thrown by the target of an invocation. ---> System.Net.WebException: The underlying connection was closed: Could not establish trust relationship for the SSL/TLS secure channel. ---> System.Security.Authentication.AuthenticationException: The remote certificate is invalid according to the validation procedure.
   at System.Net.Security.SslState.StartSendAuthResetSignal(ProtocolToken message, AsyncProtocolRequest asyncRequest, Exception exception)

Do we need to do something on web servers IIS or may be in database in order to update the new certificate? Appreciate any help.

Priyank Goel